Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts
نویسندگان
چکیده
منابع مشابه
Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts.
Brains of patients affected by Alzheimer's disease (AD) contain large deposits of aggregated amyloid β-protein (Aβ). Only a small fraction of the amyloid precursor protein (APP) gives rise to Aβ. Here, we report that ∼10% of APP undergoes a post-translational lipid modification called palmitoylation. We identified the palmitoylation sites in APP at Cys¹⁸⁶ and Cys¹⁸⁷. Surprisingly, point mutatio...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2013
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4704-12.2013